Symbol
Name
ID

Zap70
zeta-chain (TCR) associated protein kinase
MGI:99613

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Decreased lymphocyte proliferation in response to mitogen

Panhypogammaglobulinemia

Autoimmune hemolytic anemia

Eosinophilia

Abnormal B cell count

Decreased proportion of CD8-positive T cells

Absence of CD8-positive T cells

Lymphocytosis

Impaired lymphocyte transformation with phytohemagglutinin

Autoimmune thrombocytopenia

Lymphoma

Lymphoproliferative disorder

Splenomegaly

Hepatosplenomegaly

Disease(s) Associated with ZAP70

immunodeficiency 48

Mouse Phenotypes

decreased T cell proliferation

abnormal thymus cell ratio

thymus hypoplasia

abnormal thymocyte activation

abnormal class switch recombination

abnormal T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal T cell selection

abnormal T cell clonal deletion

abnormal positive T cell selection

abnormal double-positive T cell morphology

increased double-positive T cell number

arrested T cell differentiation

impaired hematopoiesis

increased B cell number

abnormal T cell subpopulation ratio

decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

absent CD4-positive, alpha-beta T cells

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

absent CD8-positive, alpha-beta T cells

increased memory T cell number

abnormal regulatory T cell number

decreased regulatory T cell number

decreased T cell number

absent T cells

increased activated T cell number

abnormal CD4-positive, alpha beta T cell morphology

abnormal splenic cell ratio

increased IgE level

increased IgG1 level

increased IgG2b level

decreased IgG level

increased immunoglobulin level

abnormal T cell physiology

abnormal T cell activation

abnormal regulatory T cell physiology

Availability

Mouse Genotype

Zap70^m1Btlr/Zap70^m1Btlr

Zap70^m1Saka/Zap70^m1Saka

Zap70^m2Btlr/Zap70^m2Btlr

Zap70^m3Btlr/Zap70^m3Btlr

Zap70^m4Btlr/Zap70^m4Btlr

Zap70^m5Btlr/Zap70^m5Btlr

Zap70^m6Btlr/Zap70^m6Btlr

Zap70^m6Hefl/Zap70^m6Hefl

Zap70^m7Btlr/Zap70^m7Btlr

Zap70^m8Btlr/Zap70^m8Btlr

Zap70^mrtle/Zap70^mrtle

Zap70^mur/Zap70^mur

Zap70^st/Zap70^st

Zap70^tm1Dlo/Zap70^tm1Dlo

Zap70^tm1Weis/Zap70^tm1Weis

Zap70^tm2.1Weis/Zap70^tm2.1Weis

Zap70^m1Saka/Zap70^tm2.1Weis

Zap70^m6Hefl/Zap70^tm1Weis

Zap70^mrtle/Zap70^rps

Zap70^st/Zap70^tm1Dlo

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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